- Wine and certain other foods contain a natural compound that activates estrogen receptors
- This compound can possibly replace hormonal treatments against the effects of menopause
What if the French understood everything? One study supports the theory that a small glass of wine a day may help you age better. Indeed, small doses of resveratrol, a natural compound found in peanuts, pistachios, grape skin, red wine, raspberries or cocoa, could activate estrogen receptors, according to research published in the journal Scientific reports. This hormone is a natural product for both men and women. And most gens have had a role to play in regulating reproduction, protecting against certain diseases of life, such as type 2 diabetes, Alzheimer’s disease or osteoporosis.
Estrogen receptors activate proteins called sirtuins in the body. The latter participated in the control of mitochondrial biogenesis, DNA repair and metabolic regulation. For biologists, sirtuins would be excellent and potential drug targets.
“Many animal studies have suggested that these proteins may prolong healthy life by preventing or slowing the onset of disease.after Henry Bayele, PhD in Molecular Biology from University College London, UK. However, the development of effective medical or dietary treatments has led to a lack of consensus on the exact function of the body’s cells.he says.
To find out more, Bayele and colleagues exhibited liver cells in vitro to various food compounds that activate sirtuins: resveratrol and isoflavones, such as daidzine, found in soy and other legumes. These compounds are collectively referred to as food sirtuin activation or dSTAC.
Low doses are then found, resveratrol increases sirtuin signaling in cells in imitation of estrogen. However, at high doses, it would decrease the signaling of sirtuins. More than isoliquiritigénine, presented in licorice, would be even more effective in activating sirtuins.
Therefore, dSTACs can be considered “vegetal estrogens”, according to Henry Bayele. They are able to perform functions that are primarily reserved for estrogen and can therefore be beneficial to the brain, liver, skeletal muscle and bones.
The “French paradox”
This study is an argument for the theory that a glass of red wine a day, no more, promotes good aging. According to Bayele, this could explain the “French paradox”. It has been shown that some people in France have lower rates of cardiovascular disease and certain types of cancer despite a high-fat diet.
“Low regular doses of resveratrol, for example, by consuming red wine as part of a healthy diet, should induce the benefits of estrogen. This would apply to men and women of all ages, but menopausal women could benefit the most, as they have lower estrogen reserves than men of the same age.“In the long run, these results may lead to the development of hormone replacement therapy (HRT) alternatives to combat menopausal symptoms, and HRT is known to have side effects: increased risk of stroke. heart attack and certain types of cancer.
But before that, clinical trials will be needed: the effects of dSTAC on cells in vitro may not reflect their effects in humans, Bayele warns. By way of illustration, if the body can digest the compounds in the gut, they could be poorly absorbed into the bloodstream. In summary, further research is needed to confirm and gens can use dSTAC as an estrogen substitute for healthy aging.
The eternal debate over the daily glass of red wine
This study is not the first to look at the benefits of resveratrol for the body. A previous thing was done on des rats, the conclusions of which were published in the journal Frontiers in physiology, indicated that this compound would be able to preserve the muscle strength of astronauts sent to Mars. “Resveratrol has been shown to preserve bone and muscle mass in rats when fully unloaded, similar to the microgravity of spaceflight. Therefore, we hypothesized that a moderate daily dose would also help reduce muscle deconditioning to a similar severity to that felt on Mars.“, the researchers summarized.
According to previous work from the University of New Brunswick (Canada), resveratrol could be a “effective alternative to medications to treat people with depression and anxiety disorders“.
The effects of drinking a glass of red wine during the day on cardiovascular health have been debated for years. While French researchers showed in 2004 that very modest consumption improved it, as well as blood pressure and cholesterol, and also decreased the risk of certain cancers, a British study published in The Lancet denied these results. According to these scientists, there would be no benefit in drinking a glass of wine every day, quite the contrary. In fact, according to them, this habit would increase the risk of stroke by 10 to 15%.
When in doubt, the National Association for the Prevention of Alcohol and Addiction recommends “limit your consumption to a maximum of two drinks a day and not drink alcohol every day ”.