A study proves the effectiveness of vitamin D for limiting deaths in the elderly

The results published on Tuesday conclude that the administration of a high dose of vitamin D within 72 hours of diagnosis Covid-19 significantly lowered the risk of death.

Dévoilés on Tuesday 31 May, the results of the COVIT-TRIAL study published in the journal Plos Medicine Vitamin D is effective in limiting mortality from Covid-19 infection in adults.

“This result is important and consistent with what we know about the anti-inflammatory effects of vitamin D, significantly reducing the risk of death at 14 days, and clearly avoiding inflammatory rash,” he wrote in a statement. the press. Professor Cédric Annweiler, head of the geriatrics department at the Angers University Hospital, is behind the study.

A clue considered from the beginning of the epidemic

From the outset of the Covid-19 epidemic, the Dest vitamin track appeared in the medical profession as a possible treatment to limit the effects of the infection. Cédric Annweiler recalls that as early as March 2020, he considered this possibility, given the properties of the vitamin that were known at the time.

Synthesized in the human body from the sun’s rays, vitamin D is recognized for its anti-inflammatory effects of infectious and cancerous diseases. In addition, to withdraw into the human body, Covid-19 uses the ACE2 protein, which is inactivated. However, vitamin D has the opposite effect. It regulates the expression of ACE2, thus limiting the effects of Covid-19 in humans.

“That’s why we quickly imagined, as early as March 2020, that vitamin D could help fight the severe forms of Covid-19,” adds Professor Annweiler.

Study labeled “national search priority”

Launched in April 2020, the COVIT-TRIAL study, labeled a national research priority in the state, was designed to assess the effect on mortality of a high dose of vitamin D in carriers. du Covid-19, but also to measure the safety of the administration of a strong amount of vitamins.

Pour ce faire, 260 patients were treated between April and December 2020, in new French hospitals. Those of Angers, Bordeaux, Limoges, Nantes, Nice, Saint-Etienne, Tours, Le Mans and Saumur, as well as the Ehpads dependent on these establishments.

Selected patients were either 65 years of age or older with “unfavorable outcome criteria,” or patients 75 years of age or older. All touched by Covid-19.

These volunteers were then divided into two groups. Those who receive a high dose of vitamin D within 72 hours of diagnosis and those who receive a normal dose. From the 6th day of treatment, the results were convincing. Doctors observed “a significant and statistically significant reduction in the risk of death” in the group that received a high dose of vitamin D.

The effect on mortality lasts for 14 days, and this without the adverse effect associated with the massive intake of vitamin D. It is only after 28 days that the effectiveness decreases.

A deficiency that can be considered a comorbidity

Results that lead to a clear conclusion. The study’s authors recommend early administration of a high dose of vitamin D, described as a “simple and safe treatment” for Covid-19 infection in the elderly. Especially since vitamin D also helps regulate cellular immunity.

More broadly, a vitamin D deficiency in a patient could be a comorbidity compared to Covid-19, as is obesity. Unless, of course, vitamin D care can be treated quickly. “Hypovitaminosis (deficiency, ed.) Is a risk factor that can be easily modified by a simple medical supplement,” the study said in a statement.

Results that come as a spy for the few thousand patients still hospitalized in France with Covid-19, 14,850 on June 1. “If the latest wave of the Covid-19 epidemic subsides, hospitalizations for patients with Covid-19 – especially the elderly – have never stopped,” the statement warned.

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